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The effect of hyperbaric oxygen on the expression of Bcl-2 in brain after persistent focal cerebral ischemia in rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-6906.2001.04.012
- Key Word:
- 高压氧;脑缺血;B细胞淋巴瘤-2
Abstract： 目的探讨高压氧(HBO)治疗对大鼠局灶性脑缺血的作用及其机制.方法应用线栓法制作大鼠局灶性脑缺血模型.70只健康雄性SD 大鼠,随机分为假手术组,缺血对照组,缺血+HBO组,缺血+高压空气组.每大组再各分5小组(n＝4),分别对应6,24,48,72 h及7 d时间点断头取脑.观察各组大鼠梗塞灶体积及Bcl-2蛋白合成,并进行组间比较.结果早期应用HBO能减少梗塞灶体积,提高半暗带内Bcl-2蛋白的合成.结论早期应用HBO可能对治疗急性脑缺血有效.
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