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Study on the therapeutic effect of combined alendronate and caltrate D on osteoporosis in elderly type 2 diabetic women and on its influencing factors
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2012.09.013
- Key Word:
- 糖尿病,2型;骨质疏松;治疗结果;阿伦膦酸盐;影响因素
Abstract： 目的 研究阿伦膦酸盐联合钙尔奇D治疗老年女性T2DM患者骨质疏松疗效的影响因素. 方法 老年女性T2DM骨质疏松患者67例,随机接受钙尔奇D或阿伦膦酸盐联合钙尔奇D治疗6个月,检测治疗前后骨密度(BMD)及生化、骨盐代谢指标. 结果 阿伦膦酸盐联合钙尔奇D疗效优于钙尔奇D.与联合治疗6个月腰椎、髋骨BMD改善正相关的指标:FPG(r=0.287和0.160)、HbA1c(r =0.283和0.110)、糖尿病病程(r=0.137和0.072)、治疗中增加胰岛素的剂量(r=0.201和0.082)、HbA1c降低幅度(r=0.302和0.139)、尿钙/Cr(r=0.115和0.096)、尿羟脯氨酸/Cr(r=0.132和0.123)、血清抗酒石酸酸性磷酸酶(r=0.204和0.296)、血碱性磷酸酶(r=0.184和0.073)、骨钙素(r=0.149和0.065)、骨碱性磷酸酶(r=0.263和0.486)(P均＜0.05).而与FC-P水平(r=-0.136和-0.212)、24 h UA1b(r=-0.220和-0.077)和基线时的骨密度(股骨颈)(r=-0.316和-0.245)负相关(P均＜0.05). 结论 阿伦膦酸盐联合钙尔奇D治疗老年女性T2DM患者骨质疏松,病情越重者获益越多,但大量UAlb影响疗效.
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