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Association between plasma Klotho levels and insulin resistance in type 2 diabetic patients
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2012.09.002
- Key Word:
- Klotho蛋白;糖尿病,2型;胰岛素抵抗
Abstract： 目的 探讨血浆Klotho (KL)水平与IR的相关性. 方法 将研究对象分为T2DM组220例,对照(NC)组76名,采用双抗体夹心ELISA检测血浆KL水平,并测定血压、血脂及肾功能等,比较两组间的差异.多元逐步回归分析KL水平的影响因素. 结果 T2DM组KL水平低于NC组[(4.9±0.5)vs(5.4±0.6)ng/ml,P＜0.01],协方差分析后KL水平仍存在组间差异(P＜0.01).ISI 和血肌酐(Scr)是KL水平的独立相关因素. 结论 T2DM患者血浆KL水平降低,其水平与ISI独立相关,KL可能是一个反映患者IR及T2DM发生的监测指标.
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