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Comparative study to effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension

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Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
12
DOI:
10.3760/cma.j.issn1673-8799.2010.12.40
Key Word:
高血压病;Apelin-12;缬沙坦;氨氯地平;Hypertension;Apelin-12;valsartan;Amlodipine

Abstract: Objective To study the effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension. Methods The 110 mild and moderate hypertension patients were divided randomly into 2 groups, 58 patients were treated in valsartan, 52 patients were treated in amlodipine. 50 healthy people physical examinded were control group. All the cases were detected Apelin-12. After 16 weeks' anti-hypertensine lowering with valsartan and amlodipine for EH group, the above item was detected again. Results The plasma Apelin-12 level after treatment of valsartan and amlodipine was significantly higher than that of treatment before. The plasma Apelin-12 level after treatment of valsartan was significantly higher than that of treatment of amlodipine. Conclusion Valsartan increase plasma Apelin-12 more than amlodipine.

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