Curative effects of nerve growth factor on neonates with moderate and sever hypoxic-ischemic encephalopathy

( views:1464, downloads:0 )
CUI Jian-po(Kaifeng Childrens Hospital, Kaifeng 475000, China)
HAO Yan-feng()
Journal Title:
Volume 04, Issue 12, 2010
10.3760/cma.j.issn 1673-8799.2010.12.23
Key Word:
Hypoxic-ischemic;Brain;Nerve growth factor;Infant;Newborn

Abstract: Objective To observe the curative efects of never growth factor (NGF)on neonates with moderate and severe hypoxic-ischemic encephalopathy (HIE). Methods Eighty-six neonates with HIE were randomly divided into NGF treatment group and control group. The control group (42 cases)were received routine treatment (including cerebrolysin and citicoline) ;the treatment group (44 cages)were given NGF on the basis of routine treatment as early as possible (within 6 hours after birth). Brain CT, neonatal behavioral neuro-logical assessment(NBNA) and children' s development center of China(CDCC) at 3 and 6 months after birth were proformed in both groups. Results Brain CT, NBNA and CDCC markers in treatment group were better than those in control group (P< 0. 05). There were great diferences between two groups (P< 0. 01). Conclusion Using NGF on the basis of the routine treatment as early as possible after resuscitation can reduce markely the severity of asphyxia induced brain damage in neonates. It is very effective using NGF in treating HIE in neonates.

  • [1]邵晓梅.新生儿缺氧缺血性脑病的诊治进展及相关问题.临床儿科杂志,2007,25(3):179-182.
  • [2]Shalak L,Perlman JM.Hypoxic-ischemic brain injury in the term infant current concepts.Early Hum Dev,2004,80 (20):125-141.
  • [3]朱长连,徐法林.新生儿缺氧缺血性脑病的诊治进展.实用儿科临床杂志,2008,23(14):1062-1064.
  • [4]徐已奕,包映辉,江基尧.神经营养因子与血脑屏障的研究进展.中华神经医学杂志,2005,4(1):92-95.
  • [5]Lin J,Lu TN.Dedicated distribution of never groth factor in different forms.Clin Res,2005,9 (13):166-167.
  • [6]黄英,严超英.碘标记神经生长因子在缺氧新生鼠脑内的吸.实用儿科临床杂志,2006,21(11):699-700.
  • [7]魏丽夏,曹云涛,刘华庆,等.神经生长因子对新生鼠缺氧缺血性脑损伤后神经再生的影响.临床儿科杂志,2008,26(7):612-616.
  • [8]贺影忠,陈超,杨毅,等.3日龄未成熟大鼠慢性缺氧缺血脑损伤IGFl及其受体的变化.中国当代儿科杂志,2005,7(3):193-198.
  • [9]薛小平.血脑屏障研究进展.微循环学杂志,2006,16(3):64-68
  • [10]Tirassa P,Manni L,Aloe L,et al.Cholecystokinin-8 and nerve growth factor:two endogenous molecules working for the upkeep and repair of the nervous system.Curt Drug Targets CNS Neurol Kisord,2002,1 (5):459-510.
  • [11]黄家俊,罗华.神经生长因子促进中枢神经系统损伤后神经再生的作用机制.医学综述,2008,14(3):330-332
  • [12]吴小平,李倩茗.实验性脑出血6个月内神经行为学和神经胶质细胞的变化.中国临床康复,2003,7(13):1888-1889.
  • [13]Anthes DL,LeBoutillier JC,Petit TL.Structure and plasticity of newly formed adult synapse.A morphometric study in the rat hippocampus.Brian Res,1993,626(12):50-62.
  • [14]Chierzi S,Ratto GM,Venna P,et al.The ability of axon to regenerate theirtowth cones depends on axonaltypeandage,and is regulated by calcium,cAMP and ERK.Eur J Nenresci,2005,21 (8):2051-2062.
  • [15]常丽英.环磷酸腺苷-蛋白酶A信号系统参与神经生长因子促进脑缺血再灌注大鼠轴突再生.中华老年心脑血管病杂志,2006,8(5):350-353.
  • [16]Wang KC,Kim JA,Sivasankaran R,et al.p75 interacts with the Nogo receptor as a CO-receptor for Nogo,MAG and OMgp.Nature,2002,420 (6911):74-78.
  • [17]Keams SM,Laywel ED,Kukekov VK,et al.Extraceluar matrix efects on neurosphere cell motility.Neurol,2003,182 (1):240 -244.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615