Irbesartan in type 2 diabetic nephropathy treatment of microalbuminuria

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WANG Ming-guan(Department of Endocrinology, First People's Hospital of Shangqiu , Henan 467100, China)
Journal Title:
Volume 04, Issue 12, 2010
10.3760/cma.j.issn 1673-8799.2010.12.14
Key Word:
Type 2 diabetic nephropathy;Microalbuminuria;Irbesartan

Abstract: Objective To observe irbesartan combined conventional therapy in treating type 2 diabetic patients with microalbuminuria results. Methods 80 cases in hospital with type 2 diabetic patients with microalbuminuria were randomly divided into two groups, in the conventional hypoglycemic, anticoagulant, lipidlowering, low-protein diet on the basis of the treatment, the treatment group:plus Heuberger losartan; control group: conventional treatment without irbesartan. All patients before treatment and at 3 months of treatment, at 6months for blood glucose determination of flight(FBG), postprandial blood glucose(PBG), endogenous creatinine clearance rate(Ccr), blood urea nitrogen(BUN), 24 h Upro, UAER, ACR test, then the two groups before and after treatment were analyzed. Results The treatment group of type 2 diabetic nephropathy in patients with microalbuminuria, in the conventional hypoglycemic, anticoagulant, lipid-lowering, low-protein diet based treatment, on the plus irbesartan, treatment for 3 nonths, 6 months after the 24 h Upro, UAER, ACR significantly better than the control group. Conclusion Irbesartan treatment of type 2 diabetic microalbuminuria in clinical efficacy and reliable.

  • [1]朱禧星,糖尿病.实用内科杂志.人民卫生出版社,2001:958.
  • [2]姜傥,尿液蛋白与肾脏病.中华检验医学杂志,2002,25(5):312-313.
  • [3]李庆华,金鲜花.尿微量白蛋白检测对糖尿病早期损伤的诊断价值.中华临床医学研究杂志,2006,12(1):117-118.
  • [4]严钟德,王波,李荣.2型糖尿病患者血管内皮损伤与糖尿病肾病关系的探讨.中华内分泌代谢杂志,2000,16(3):260-261.
  • [5]Hirano T,Kashiwazaki K,Moritomo Y,et al.Albuminuria isdirectly associated with increased plasma PAF1 and factor Ⅶlevels in NIDDM patients J.Diabetes Res Clin Pract,1997,36 (1):11-18.
  • [6]周华,王力宁,范秋灵,等.胰岛素及卡托普利对糖尿病大鼠肾小球蛋白激酶C活性的影响.中华肾脏杂志,2001,17(3):196-198.
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