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2006~2009 years,Escherichia coli producing extended β-lactamase detection and monitoring of drug resistance

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Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
9
DOI:
10.3760/cma.j.issn1673-8799.2010.09.25
Key Word:
埃希氏菌属;β-内酰胺酶类;抗药性,细菌;感染;Escherichia spp;β-lactamases;Resistant bacteria;Infection

Abstract: Objective To understand the key of E.coli infection in the hospital ward of the distribution and capacity for extended spectrum β-lactamases (extended-spectrum β-lactamase,Esbls) situation monitoring and analysis of drug resistance of Escherichia coli,clinical therapy.Methods Between 2006 ~ 2009 hospitalized patients infected Escherichia coli isolated from the conventional method or the CNI system identification,KB method for drug susceptibility testing,with the screening test and confirmatory test to confirm production ESBLS bacteria and SPSS11 with WHOVET5.3.0 software for analysis.Results A total of 456 E.coli isolated,193 strains producing ESBLS detection ESBLS (+) rate of 42.3%.In addition to 100% sensitive to imipenem,the resistance of bacteria producing ESBLS significantly higher than non-producing ESBLS strains,especially in the 3rd generation cephalosporin resistance in two significantly different compared (P > 0.01).Ward distribution in the order of:ICU > Respiratory Medicine > Pediatrics > General Surgery etc..From 4-year monitoring results,E.coli producing ESBLS (+) rate has increased year by year,and presented a multi-and cross-resistance.Conclusion The first hospital E.coli infection,the positive detection rate increased year by year and 3rd generation cephalosporins consistent with a large number of applications,the emergence of multiple drug resistant and unreasonable application of broad-spectrum antibiotics have a certain relationship.ICU,respiratory medicine,paediatrics ward and other patients in urinary tract,respiratory system infections,etc.,should first consider the result as Escherichia coli,should be based on in vitro bacterial culture and drug susceptibility testing and ESBLS bacteria test results,the rational use of antibiotics and dynamic monitoring of drug resistance change ,the establishment of rational antibiotic use rotation system to prevent resistant strains producing ESBLS production,proliferation and popularity.

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