Abstract： Objective To evaluate the usefulness of serum alpha-fetoprotein(AFP) and carcinoemb-ryonic antigen (CEA)carcinoma in clinical diagnosis and screening for primary hepatic carcinoma (PHC).Methods Totally 201 PHC patients,73 liver cirrhosis patients,and 54 healthy subjects were enrolled in this study.All of the sample were measured by microparticle chemiluminescent immunoassay.Results The serum AFP level was significantly higher in PHC patients than in liver cirrhosis patients and healthy subjects.The serum AFP level was increase in liver cirrhosis patients too.The serum AFP level was extremely increased in PHC patients,it could be up to 6027 μg/L,and it also increased in liver cirrhosis patients,it could be up to 1880 μg/L.Sensitivity and specificity of AFP at 20 μg/L cut-off was 73.13% and 38.36%.Sensitivity and specificity of AFP at 400 μg/L cut-off was only 44.28% and 80.43%.The serum CEA level was( 13.4 ± 32.6) μg/L,which was significantly higher than the other two group (P ＜ 0.01 ).Conclusion AEP increase on strong HCC diagnosed with hints of function,increase the CEA value for high-risk patients with positie screening for AFP and plays on important role in the follow-up.