Abstract： Objective To monitor the therapeutic action and security of mitomycin C associate with steroid injected to keloid.Methods 48 patients were treated merely with corticosteroid injection to keloid,once in 2weeks.The other 42 patients around sternal area were treated with intralesional injection of a mixture of 0.04 mg mitomycin C ,5 ml corticosteroid and 1 ml 2% lidocaine once per 2-4 weeks.After keloid r became flattened,drug concentration was decreased with prolonged intermission of drug injection.Results The total therapy efficacy of mitomycin C associate with steroid to keloid was 97.62%.the complete remission percentage was 45.23% ,the large remission percentage was 47.62% ,part remission percentage was 4.72% ,and the inefficacy percentage was 2.38%.Conclusion It is more effective that the combination therapy to keloid of low concentration nitomycin C and steroid.