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The investigation of the effects of Clopidogel on the arterial anglopathies of lover extremity in 68 patients with 2 diabetes

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Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
11
DOI:
10.3760/cma.j.issn1673-8799.2009.11.03
Key Word:
2型糖尿病;下肢动脉病变;硫酸氢氯吡格雷;Doppler;阿司匹林;踝肱比;Type 2 diabetes;Artery of lower extremity;Angiopathy;Clopidogrel;Color Doppler;Aspirin;ABI

Abstract: Objective To investigate the effects of Clopidogrel on the arterial angiopathies of lower extremity in 68 patients with type 2 diabetes.Methods 98 type 2 diabetic patients with lower extremity arterial disease diagnosed by ankle-braehial index(ABI)and color Dopplor were randomly divided into two groups,Clopidogrel group which received the treatment of Clopidogrel 75 mg a day for 6 months,Aspirin group which received the treatment of Aspirin 75 mg a day for 6 months.Before and after treatment,the inner diameter of the femoral artery,pepliteal artery,dorsal pedal artery and the blood current velocity of lower extremity and ABI were measured by Doppler.The clinic symptoms of lower extremity and the side effects weIe also observed.Resuits In Clopidogrel group,the inner diameters of pepliteal artery,dorsal pedal artery and the maximum velocity of blood current in artery of lower extremity were increased significantly,P value<0.05.The inner diameters of each artery and blood current velocity in the Aspirin group showed some improvement but without significant difference(P value>0.05).The efficacy rates of the treatment in Clopidogrel group reached 81.38%and 52.24% in Aspirin group,the difference of the efficacy rate in two groups was significant(P value<0.05).No remarkable adverse reactions occurred during the study.Conclusoin Long-terra Clopidogrel therapy could effeetively delay the progression of angiopathy in artery of lower extremity in patients with type 2 diabetes.

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