Abstract： Objective To explore the value of Sedative/analgesic and narcotic in the savary dilator in the treatment of esophageal stenosis. Methods 45 cases of patients were divided into 3 groups: Pharyngeal sur-face anesthesia group; conscious sedation and intravenous anesthesia, Observation Group 3 patients with adverse reactions, as well as pre-treatment, treatment, treatment of blood pressure, respiration, heart rate and oxygen satu-ration changes. Results Pharyngeal surface anesthesia group Significant stress、cough、 extubation act, and other adverse reactions, Intraoperative breathing, heart rate and blood pressure increased significantly (P<0.05), but in the normal range, Oxygen saturation did not change much; Sedation group significantly reduced side effects,patients in breathing,heart rate and blood pressure than before no significant changes occur hypoxemia 2; intra-venous anesthesia group, patients with intraoperative tolerance, and less adverse reactions; but the average intra-operative Blood pressure was significantly lower than before (P<0.05); breathing, heart rate than the pre-oper-ative has been slow, but the difference was not statistically significant (P>0.05), hypoxemia occurred in 4 ca-ses. Conclusion In the endoscopic treatment, a reasonable choice of sedation/anesthesia and analgesic tech-nique will help improve patient compliance and tolerance,To make treatment more economic, safety, comfort.