Abstract: Objective Investigation the relationship between the chronic hepatitis B patients quality of life and social and family status.Methods Using a questionnaire survey,random sample of 288 out-patient and hospitalization of patients with hepatitis B.Results The chronic hepatitis B patients quality of life and the status of social and family have a positive correlation.ConclusionNurses should actively mobilize all Support.such as social forces and the patient's family initiative,in order to maximize the improvement of the quality of life of hepatitis B patients.