Abstract: Objective To study the feasibility of individualized sodium hemodialysis therapy for hemo dialytic patients with refractory hypertension.Methods 26 patients were applied individualized sodium hemodi alysis based on the plasma sodium before hemedialysis,blood pressure and anti-hypertensive recipe were moni toted during 8-week treatment.Results The blood pressure was decreased significantly after 8-week treatment (SBP 173±24 vs 135±13 mm Hg,DBP 100 ±17 vs 87±7 mm Hg)and expense of anti-hypertensive recipe was decreased(17.4 ±3.4 vs 12.2±2.6 RMB/d).Conclusion Individualized sodium hemodialysis is an effective therapy for hemedialytic patients with refractory hypertension,and lower expense of anti-hypertensive.