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The Expression Of Nuclear Factor-κB And Cyclooxygenase 2 In Large Bowel Carcinoma And Their Relation To Angiogenesis

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Author:
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Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
1
DOI:
No doi available
Key Word:
大肠癌;核因子-κB;环氧合酶2;微血管密度

Abstract: 目的 探讨核因子-κB(NF-κB)和环氧合酶2(Cox-2)在大肠癌中的表达及其与微血管密度(MVD)之间的关系. 方法 应用免疫组化SP法检测72例大肠癌组织NF-κB、Cox-2和MYD的阳性表达. 结果 大肠癌组织的NF-κB和Cox-2的阳性表达率明显高于正常结肠黏膜.大肠癌组织NF-κB的阳性表达和肿瘤淋巴结转移、肝转移以及Dukcs分期密切相关.Cox-2的阳性表达和大肠癌的局部浸润深度、淋巴结和肝转移以及Dukes分期均具有显著相关性.NF-κB阳性表达的大肠癌组织中Cox-2的阳性表达率明显高于NF-κB表达阴性者.NF-κB阳性表达组或Cox-2阳性表达组大肠癌MVD数量显著高于NF-κB阴性表达组或Cox-2阴性表达组. 结论 NF-κB和Cox-2参与了大肠癌的发生、浸润和转移.它们在大肠癌的血管形成中起重要作用.

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