Systematic review of 47 cases of primary small cell carcinoma of the pancreas
- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1674-1935.2012.04.003
- Key Word:
- 神经内分泌瘤;癌,小细胞;胰腺;Meta分析;Neuroendorine tumors;Carcinoma,small cell;Pancreas;Meta-analysis
Abstract： Objective To investigate the clinicopathologic features,therapy,and prognosis of primary small cell carcinoma of the pancreas.Methods Databases including Chinese Journal Full-text Database,VIP Database for Chinese Technical Periodicals,Medline/Pubmed,and OVID were searched electronically up to April 2012.A systematic review was performed together with one case in our hospital.Results Twenty-eight articles fulfilling the criteria consisting of 46 patients with pathologically confirmed diagnosis of primary small cell carcinoma of the pancreas were studied,together with 1 patient in our Drum Tower Hospital,finally 47patients were included.The results of this systematic review showed:( 1 ) Primary small cell carcinoma of the pancreas was more common in men with a median age of 62.The most common clinical presentations were abdominal pain,jaundice and weight loss.Para-neoplastic syndrome was rarely observed.(2)Most cases were found to have abnormally elevated serum levels of neuron-specific enolase.CT displayed heterogeneous,and marked enhancing masses in most cases.The conclusive diagnosis depended on histological confirmation.(3)63.8％ of the cases were found to be associated with metastasis at the time of diagnosis.The overall median survival time was 28 weeks.(4) There was no consensus on the treatment of primary small cell carcinoma of the pancreas. Chemotherapy was currently considered as the treatment of choice among the systematic management for these patients.Conclusions Primary small cell carcinoma of the pancreas was a rare and aggressive neuroendocrine tumor with a poor prognosis.
- [1]李荣强,高春妮,张晓康,等.胰尾部胰腺小细胞癌误诊1例[J].2001,(19).
- [2]周莉,侯安继.胰腺小细胞癌术后长期存活一例[J].2011,(5).
- [3]Min Sung Chung,Tae Kyung Ha,Kyeong Geun Lee,etc.A case of long survival in poorly differentiated small cell carcinoma of the pancreas[J].2008,(31).
- [4]吕叶,王宁菊,马涛.胰腺神经内分泌癌2例并文献复习[J].2009,(6).
- [5]冀子中,邬万新,朱文君.无功能胰腺神经内分泌癌[J].2009,(10).
- [6]David S. Klimstra,Seung Mo Hong,Jason Y. Park.Pdxl Expression in Pancreatic Precursor Lesions and Neoplasms[J].2011,19(5).
- [7]van der Heijden HF,Heijdra YF.Extrapulmonary small cell carcinoma.[J].2005,98(3).
- [8]T, Morikawa,S, Kobayashi,I, Yamadori,etc.Three cases of extrapulmonary small cell carcinoma occurring in the prostate, stomach, and pancreas.[J].1994,31.
- [9]Dansong, Wang,Yefei, Rong,Wenchuan, Wu,etc.Primary small cell carcinoma of the pancreas: rare type of pancreatic cancer and review of the literatures.[J].2012,10.
- [10]Ralph H Hruban,Laura H Tang,Yi Zhong,etc.Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors.[J].2012,36(2).
- [11]T, Namieno,K, Koito,T, Nagakawa,etc.Diagnostic features on images in primary small cell carcinoma of the pancreas.[J].1997,92.
- [12]B, Corrin,E D, Gilby,N F, Jones,etc.Oat cell carcinoma of the pancreas with ectopic ACTH secretion.[J].1973,31(6).
- [13]Katsuno A,Nakamura Y,Arima Y,etc.Changes to levels of serum neuron-specific enolase in a patient with small cell carcinoma of the pancreas.[J].2005,12(1).
- [14]R, Chetty,S P, Clark,G A, Pitson.Primary small cell carcinoma of the pancreas.[J].1993,25.
- [15]R D, Hobbs,A F, Stewart,N D, Ravin,etc.Hypercalcemia in small cell carcinoma of the pancreas.[J].1984,53(7).
- [16]A, Van Der Gaast,J, Verwey,E, Prins,etc.Chemotherapy as treatment of choice in extrapulmonary undifferentiated small cell carcinomas.[J].1990,65(3).
- [17]N A, Wahid,A I, Neugut,H, Hibshoosh,etc.Response of small cell carcinoma of pancreas to a small cell lung cancer regimen: a case report.[J].1996,14.
- [18]R, Morant,H W, Bruckner.Complete remission of refractory small cell carcinoma of the pancreas with cisplatin and etoposide.[J].1989,64(10).
- [19]Kitano M,Komaki T,Sakamoto H.Small cell carcinoma of the pancreas: role of EUS-FNA and subsequent effective chemotherapy using carboplatin and etoposide.[J].2009,44(5).
- [20]C V, Reyes,T, Wang.Undifferentiated small cell carcinoma of the pancreas: a report of five cases.[J].1981,47(10).
- [21]R, Lebtahi,G, Cadiot,M, Mignon,etc.Somatostatin receptor scintigraphy: a first-line imaging modality for gastroenteropancreatic neuroendocrine tumors.[J].1998,115.
- [22]Eric H. Choi,Walter Coyle.A Pancreatic Mass in a Patient With Nausea and Vomiting[J].2011,140(3).
- [23]刘骞,黄帅,刘剑坡,等.胰腺神经内分泌癌的诊断及外科治疗（附10例临床报告）[J].2011,(3).
- [24]Nelson G. Ordónez,Karen R. Cleary and,Bruce Mackay.Small Cell Undifferentiated Carcinoma of the Pancreas[J].1997,21(5).
- [25]Francesc Casas,Ferran Ferrer,Blanca Farrús,etc.Primary small cell carcinoma of the esophagus: A review of the literature with emphasis on therapy and prognosis[J].1997,80(8).
- [26]戎叶飞,楼文晖,靳大勇.胰腺神经内分泌癌3例报道[J].2004,(16).
- [27]Koichi Motojima,Junichiro Furui,Masazumi Terada,etc.Small cell carcinoma of the pancreas and biliary tract[J].1990,45(3).
- [28]Zhong Y,Hruban RH,Laheru D,etc.Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreas.[J].2011,40(6).
- [29]C, Percy,L, Sobin.Surveillance, epidemiology, and end results lung cancer data applied to the World Health Organization's classifications of lung tumors.[J].1983,70.
- [30]Tsujimura T.Curative resection of a small cell carcinoma of the pancreas: Report of a case of long survival without chemotherapy.[J].2004,19(9).