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Expression of p57kip2, retinoblastoma protein and proliferating cell nuclear antigen in human pancreatic cancer and their relationship with clinicopathology
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1674-1935.2003.02.003
- Key Word:
- 细胞周期蛋白质类;视网膜母细胞瘤蛋白质;增殖细胞核抗原;胰腺肿瘤;免疫组织化学
Abstract： 目的探讨细胞周期蛋白依赖性激酶抑制因子p57kip2,视网膜母细胞瘤蛋白(Rb)和增殖细胞核抗原(PCNA)在胰腺癌发生发展中的作用.方法应用免疫组化技术,对32例胰腺癌及癌旁组织中p57kip2、Rb蛋白和PCNA表达进行检测.结果 p57kip2蛋白阳性表达率在胰腺癌组织中为46.9%,显著低于癌旁胰腺组织的75.0%(χ2=5.317,P < 0.05),并与胰腺癌组织分化程度有关(P < 0.05),而与淋巴结转移无关(P > 0.05).Rb蛋白阳性表达率在胰腺癌组织中为50%,显著低于癌旁胰腺组织的78.1%(χ2=5.497, P < 0.05).PCNA阳性表达率在胰腺癌组织中为71.9%,显著高于癌旁胰腺组织的43.8%(χ2=5.189, P < 0.05),并与胰腺癌组织分化程度和淋巴结转移均有关(P < 0.05) .p57kip2蛋白阳性表达组Rb蛋白阳性表达率为53.3%;p57kip2蛋白阴性表达组Rb蛋白阳性表达率为47.1%,两组间无相关性(γ=0.16507, P ＞ 0.05).结论 p57kip2、Rb蛋白低表达和PCNA蛋白过度表达与胰腺癌的发生发展有关.
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