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Selective short-term fertilization for in vitro fertilization-embryo transfer: a clinical study

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Author:
No author available
Journal Title:
Chinese Journal of Biomedical Engineering
Issue:
3
DOI:
10.3760/cma.j.issn.1674-1927.2012.03.016
Key Word:
胚胎移植;受精,体外;精子注射,细胞质内;妊娠率;Embryo transfer;Fertilization in vitro;Spem injections,intracytoplasmic;Pregnancy rate

Abstract: Objective To investigate the effects of selective short-term fertilization in combination with salvage intracytoplasmic sperm injection (ICSI) on embryo qoality and pregnancy outcome in patients at risk of fertilization failure.Methods Retrospective analysis was cooducted on patients undergoing assisted reproduction technology in Assisted Reproductive Center,The Third Affiliated Hospital of Guangzhou Medical College between September 2010 and January 2011.Patients treated with short-term fertilization (n=93) were allocated into group A and were subdivided into group A- IVF (n=58) for those with normal fertilization rate,group A-ICSI (n=21) for receiving complete salvage ICSI,and group A-half for partial salvage ICSI (n=14).In addition,those who underwent overnight fertilization were assigned into group B (n=466),and non-salvage ejaculation ICSI into group C (n=94),respectively.Bctween-group comparison was performed in the rates of fertilization,clinical pregnancy,polyembryony,miscarriage,premature delivery and birth defect.Results Group A-IVF had significantly lower fertilization rate[74.4%(588/790) vs 80.8% (4674/5782) ],lower two pronuclear(2PN) rate[45.7%(361/790) vs 64.1%(3707/5782) ],and higher OPN rate [ 14.1% (111/790) vs 2.6% (149/5782) ],as compared with group B (all P<0.05).Statistically distinct rates in terms of clinical pregnancy,polyembryony,miscarriage,premature delivery and birth defect were not yielded between group A-ICSI and group C (all P>0.05),as well as between group A-IVF and group B (all P>0.05).Group A-half was found to have lower fertilization rate than group B (72.7% vs 80.8%,P< 0.05).Conclusion Selective short-term fertilization may be useful as a result of securing the interests of most patients at risk of fertilization failure.

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