Association between cytochrome P4503A4 genotype polymorphism and drug-resistant epilepsy
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1927.2010.03.002
- Key Word:
- 细胞色素P4503A4;基因多态性;癫痫;耐药;多态性,限制性片段长度;Cytochrome P4503A4;Genotype polymorphism;Epilepsy;Drug- resistant;Polymorphism,restriction fragment length
Abstract： Objective To investigate the distribution of single nucleotide polymorphisms (SNPs) in three down - regulated CYP3A4 enzymes of cytochrome P4503A4 (CYP3A4) , and to explore their association with drug-resistant epilepsy in Southern Han Chinese. Methods Polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) method was used to detect the distribution of three SNPs (CYP3A4*4, CYP3A4*5 and CYP3A4*6) in 112 drug-resistant epilepsy cases (resistance group), and in 136 healthy people(control group). The difference in CYP3A4 genotype between two groups was analyzed.Results CYP3A4*4 and CYP3A4*6 were wildtype genotypes in all the cases and healthy people. CYP3A4*5 was a wild-type genotype in all the control people and 108 resistance group cases, except that 4 cases in the resistant group appeared to have heterozygotic CYP3A4*5. Difference between two groups was significant [136:0 vs 108: 4, OR(95%CI)=1.037(1.001-1.075), P=0.040]. Conclusion CYP3A4*5 polymorphism may be associated to drug-resistance in epilepsy.
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