You Position: Home > Paper

Correlation between HBV-DNA loads and serum AST in patients with hepatitis B

( views:209, downloads:12 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
Issue:
4
DOI:
10.3760/cma.j.issn.1674-1927.2009.04.018
Key Word:
肝炎病毒;乙型;DNA;病毒;天冬氨酸氨基转移酶类;荧光定量聚合酶链反应;血清标志;Hepatitis B virus;DNA;viral;Aspartate aminotransferases;Fluorescence quantitative polymerase chain reaction;Serum markers

Abstract: Objective To investigate the correlation between hepatitis B virus (HBV)-DNA and aspartate transaminase (AST) in two groups of hepatitis B patients--Group One (HBsAg+, HBeAg+, HBcAb+) and Group Two (HBsAg+, HBeAb+, HBeAb+). Methods The patients were divided into two groups based on status of HBV-related surface biomarkers as detected by enzyme-linked immunosorbent assay (138 in Group One and 362 in Group Two). The levels of HBV-DNA and AST were determined by fluorescence quantitative polymerase chain reaction (FQ- PCR) and enzyme coupling rate method respectively, and then the correlation was analyzed. Results Significant differences in both HBV-DNA and AST existed between Group One [(1.30±0.48)×107 copies/ml, (46±8)U/L] and Group Two [(3.87±3.12)× 102 copies/ml, (27±5)U/L] (all P<0.05). The rates of abnormal HBV-DNA (92.03%) and AST (43.48%) in Group One were higher than those in Group Two (22.10%, 21.27% )(all P<0.01 ), but no correlation was found between HBV-DNA and AST(P>0.05). Conclusions While HBV-DNA load and liver injury in Group One are more severe compared with Group Two. No correlation is found between HBV-DNA and AST. Therefore, combining HBV- DNA and AST tests would provide more accurate evaluation of viral loads in the body, and should be an important guidance in the diagnosis, treatment and prognosis prediction of Hepatitis B patients.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn