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Analysis of Cytotoxicity in T Cells from Cord Blood Induced by PML-RARα Peptide and NB4 Cells

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Author:
No author available
Journal Title:
JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
Issue:
6
DOI:
10.3760/cma.j.issn.1008-634X.2005.06.003
Key Word:
PML-RARα多肽;MLTC;NB4细胞;T细胞;细胞毒活性

Abstract: 目的了解PML-RARα多肽和NB4细胞体外诱导体外诱导增殖的T细胞的特异性细胞毒作用.方法采用混合淋巴细胞/肿瘤细胞培养(MLTC)方法,经丝裂霉素C处理的NB4细胞或PML-RARα 多肽(LSSCITQGKAIETQSSSSEE)作为刺激原体外诱导脐血单个核细胞增殖.利用LDH方法检测诱导后T细胞的细胞毒性.结果 PML-RARα多肽诱导组第10d和第15d T细胞对NB4细胞的杀伤活性为:49.65±6.7%(p<0.01)和73.13±8.42%(p<0.01),NB4细胞诱导组第10d和第15d T细胞对NB4细胞的杀伤活性为:53.33±8.82%(p<0.01)和74.46±9.57%(p<0.01),而无诱导组的第10d和第15d T细胞对NB4细胞的杀伤活性为:15.93±9.25%和38.19±10.54%,前两组T细胞对NB4细胞的杀伤作用均明显高于对照组.结论 PML-RARα多肽和NB4细胞体外可诱导出特异性T细胞,他们对表达PML-RARα的NB4细胞具有选择性杀伤作用.

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