You Position: Home > Paper
The Relationship between MMP 2,MMP 9 Expression and Clinic Pathological Features in Non-small-cell Lung Carcinoma
( views:257, downloads:0 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-634X.2005.03.004
- Key Word:
- 肿瘤;肺;非小细胞肺癌;基质金属蛋白酶
Abstract： 目的探讨MMP 2、MMP 9在非小细胞肺癌组织中的表达及其与临床病理特征的关系.方法用链菌素生物素蛋白-过氧化物酶免疫组织化学法(SP法)检测83例手术切除的NSCLC组织及其交界区组织和24例正常肺组织中MMP 2、MMP 9的表达,分析二者在肿瘤组织中的过表达与NSCLC的临床病理特征的关系.结果 MMP 2、MMP 9主要表达于肿瘤细胞的胞浆,在癌旁交界区组织也有表达,肿瘤组织的过表达率显著高于交界区(p<0.005),在正常组织中无过表达;二者的过表达与肿瘤类型、病理分级、性别、年龄、吸烟史无明显关系;MMP 2在肿瘤组织的过表达率与淋巴结转移状态及临床分期有关(p<0.05).结论 MMP 2、MMP 9都参与了NSCLC发生发展过程,并且可能对肿瘤的发生发展有促进作用,MMP 2与淋巴结转移和临床分期密切相关.
- [1]V, Ozenci,L, Rinaldi,N, Teleshova,etc.Metalloproteinases and their tissue inhibitors in multiple sclerosis.[J].1999,12(4).
- [2]S L, Parsons,S A, Watson,P D, Brown,etc.Matrix metalloproteinases.[J].1997,84(2).
- [3]M M, Mareel,F M, Van Roy,M E, Bracke.How and when do tumor cells metastasize?[J].1993,4.
- [4]Yrj? T Konttinen,Mia Ainola,Heikki Valleala,etc.Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis[J].1999,58(11).
- [5]B, Nawrocki,M, Polette,V, Marchand,etc.Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: quantificative and morphological analyses.[J].1997,72.