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Effects of IL-2 Gene Modified Tumor Cells on the Number and Functions of Peritoneal Macrophages in Vivo

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Author:
No author available
Journal Title:
JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
Issue:
5
DOI:
10.3760/cma.j.issn.1674-1927.2003.05.004
Key Word:
IL-2;基因修饰;巨噬细胞

Abstract: 目的探讨IL-2基因修饰的肿瘤细胞对小鼠体内巨噬细胞(Mφ)数量和功能的影响.方法应用腺病毒载体介导的小鼠IL-2基因(Ad-mIL-2)修饰CT26小鼠结肠腺癌细胞(CT26-mIL-2)后皮下接种小鼠,计数小鼠腹腔Mφ的数量,观察其吞噬功能,混合淋巴细胞反应法(MLR)测定其抗原提呈能力,MTT法检测其杀伤活性.结果 mIL-2基因修饰的CT26细胞(CT26-mIL-2细胞)皮下接种后,小鼠腹腔Mφ数量显著增加,吞噬能力明显增强,抗原提呈能力提高,并具有较强的杀伤活性.结论 CT26-mIL-2细胞分泌的IL-2能有效地激活Mφ,这可能是CT26-mIL-2细胞体内致瘤性下降的原因之一.

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