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Study on the Effect of Chitosan on Delaying Aging
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1927.2003.03.003
- Key Word:
- 壳聚糖 果蝇 寿命 SD大鼠 SOD MDA
Abstract： 为探讨壳聚糖在延缓衰老功能方面的作用,以Oregon K黑腹果蝇(Drosophila melanogaster)和20月龄SD雄性大鼠为研究对象,观察壳聚糖对果蝇生存时间及对大鼠血清中SOD活性、MDA含量的影响.结果发现,雌雄果蝇各剂量组的最高寿命天数均明显增高(p<0.01),雌性果蝇0.015%、0.045%、0.135%剂量组平均寿命天数较对照组延长(p<0.05),且半数死亡时间分别比对照组延长2天、8天和18天.SD大鼠血清中SOD活性升高,MDA含量下降(p<0.05).壳聚糖具有延缓衰老功能,且作用机理与其能减少机体内氧自由基水平有关.
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