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The Transcriptive Expression and Clinical Significance of nm23-H1 Gene in Human Breast Cancer with RT-PCR Method
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1674-1927.2003.02.003
- Key Word:
- 乳腺癌;nm23-H1基因;基因表达
Abstract： 目的探讨nm23-H1基因mRNA在乳腺癌组织中的表达及其与临床的关系.方法采用半定量RT-PCR方法,检测30例乳腺癌组织nm23-H1的表达.结果①淋巴结阳性的原发灶组织nm23-H1 mRNA表达明显低于淋巴结阴性的原发灶组织,Ⅲ期乳腺癌组织nm23-H1 mRNA水平较Ⅰ、Ⅱ期的明显低.②多因素分析发现淋巴结转移与nm23-H1mRNA的表达有显著性相关.结论 nm23-H1基因mRNA表达强度与淋巴结转移呈负相关.在乳腺癌转移过程中,nm23-H1 mRNA起重要的作用.
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