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Experimental Studies on Effects of GM1 Gangliosides on Hypoxic-Ischemia-Encephalopathy in Neonatal Rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1927.2002.03.006
- Key Word:
- 神经节苷脂GM1;新生鼠;缺氧缺血性脑病;Glu-IR神经元;GABA-IR神经元
Abstract： 目的探讨单唾液酸四己糖神经节苷脂(GM1)对新生大鼠缺氧缺血性脑病(HIE)及其后的癫痫发作是否具有保护和预防作用以及可能作用机理,为临床应用GM1治疗HIE提供理论依据. 方法建立新生大鼠HIE模型,用组织化学方法和免疫组织化学方法观察缺氧缺血后脑损害的形态学改变、兴奋性氨基酸Glu阳性(Glu-IR)神经元和抑制性氨基酸GABA阳性(GABA-IR)神经元表达和GM1对上述变化的影响. 结果盐水处理组与GM1治疗组相比病变较重, Glu-IR神经元和GABA-IR神经元数目减少与GMI治疗组差异有显著性意义. 结论 GM1能够在一定程度上减轻新生大鼠缺氧缺血后病损灶,保护Glu-IR神经元和GABA-IR神经元,尤其是对GABA-IR神经元的保护作用,提示GM1对新生大鼠缺氧缺血后的癫痫发作具有一定的预防作用,但尚需进一步探讨研究.
- [1]赵传胜,王慕一,高旭光,等.大鼠局灶脑缺血再灌注后GM1的保护作用及其对FGFR1表达的影响[J].1999,(1).
- [2]朱长庚,蔡秋云,刘庆莹,等.大鼠海马内谷氨酸神经元与GABA神经元之间突触联系的免疫电镜双标研究[J].1995,(1).
- [3]徐仁泗,黄怀钧,王凤霞,等.神经节苷脂对缺血性大鼠脑保护作用的研究[J].1999,(3).
- [4]B W, Peeters,G M, Ramakers,B A, Ellenbroek,etc.Interactions between NMDA and nonNMDA receptors in nonconvulsive epilepsy in the WAG/Rij inbred strain.[J].1994,33(6).
- [5]H J, Romijn,R A, Voskuyl,A M, Coenen.Hypoxic-ischemic encephalopathy sustained in early postnatal life may result in permanent epileptic activity and an altered cortical convulsive threshold in rat.[J].1994,17(1).
- [6]B W, Peeters,G M, Ramakers,J M, Vossen,etc.The WAG/Rij rat model for nonconvulsive absence epilepsy: involvement of nonNMDA receptors.[J].1994,33(6).
- [7]主编韩玉昆, 许植之, 虞人杰.新生儿缺氧缺血性脑病[M].2000.
- [8]M.J. During,D.D. Spencer.Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain[J].1993,341(8861).
- [9]沈鼎烈.临床癫痫[M].1994.