Abstract： Objective To study the distribution of Apo E gene in patientswith Alzheimer desease, and analyse the relation between them . Methods ApoE genotyes of patients with Alzheimer desease and age-matched healthy controls were determined by using the polymerphism technique,subsequently to require the ralation between ApoE allele and AD . Results ApoE ε4 allele of patients with AD was 20.4%,which obviously was higher than 7.5% of cotrols, but ε3 allele of patients with AD was 64.8%, which was lower than 83.2% of cotrols.Conclusions In ApoE allele, ε4 allele is a genetic suscetible factor in AD,and ε3 allele is a protection factor.