Hair follicle stem cells in disorders characterized by alopecia

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GUAN Hai-hong(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042; Department of Dermatology, Nanjing General Hospital of Nanjing Military Command,Nanjing 210002, China)
LI Hong-xin(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042)
LIN Lin(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042)
Journal Title:
International Journal of Dermatology and Venereology
Volume 38, Issue 05, 2012
Key Word:
Hair follicle; Stem cells; Alopecia

Abstract´╝Ü Alopecia,as a common disease,is generally classified into two groups,cicatricial and noncicatricial alopecia,according to clinical presentations and regrowth capability of hairs,and each group includes various types of alopecia.The pathogenesis of alopecia remains poorly understood.Hair follicle stem cells are located in the bulge area,whose periodic proliferation and differentiation sustain the growth,shedding and regrowth of hairs.Recent research has indicated that the damage or deficiency of hair follicle stem cells may contribute to the pathogenesis of some types of alopecia,especially cicatricial alopecia.

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