Molecular mechanisms underlying the induction of vascular endothelial growth factor expression by pituitary tumor transforming gene

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CAO Hua-li(Department of Dermatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China)
ZHENG Min(Department of Dermatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China)
Journal Title:
International Journal of Dermatology and Venereology
Volume 38, Issue 05, 2012
Key Word:
Neoplasms; Blood vessels; Pituitary neoplasms; Vascular endothelial growth factor

Abstract: Pituitary tumor transforming gene (PTTG) can induce the expression of vascular endothelial growth factor (VEGF),one of the most important angiogenic growth factors for tumor angiogenesis,to promote tumor angiogenesis.It has been revealed that PTTG can transactivate the inhibitor of DNA binding-3 (ID3)and fibroblast growth factor-2 (FGF-2) by interacting with PTTG binding factor (PBF) and specificity protein 1 (Sp1).PTTG can also regulate the transcription of matrix metalloproteinase-2 (MMP-2),thrombospondin-1 (TSP-1) and thioredoxin-1 (Trx-1) through other pathways,which are all involved in the mechanisms underlying the induction of VEGF expression by PTTG.

  • [1]Winnepenninckx V,Debiec-Rychter M,Belien JA,et al.Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma.Mod Pathol,2006,19 (9):1170-1180.
  • [2]杨萍,郑敏.血管内皮细胞生长因子家族及其受体与表皮黑素瘤的关系.国际皮肤性病学杂志,2009,35(6):385-387
  • [3]Hamid T,Malik MT,Kakar SS.Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells.Mol Cancer,2005,4(1):3.
  • [4]Kim CS,Ying H,Willingham MC,et al.The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer.Carcinogenesis,2007,28 (5):932-939.
  • [5]Kim DS,Franklyn JA,Boelaert K,et al.Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway.J Clin Endocrinol Metab,2006,91 (11):4603-4611.
  • [6]Tong Y,Tan Y,Zhou C,et al.Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition.Oncogene,2007,26(38):5596-5605.
  • [7]Watkins RJ,Read ML,Smith VE,et al.Pituitary tumor transforming gene binding factor:a new gene in breast cancer.Cancer Res,2010,70(9):3739-3749.
  • [8]Chintharlapalli S,Papineni S,Lee SO,et al.Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins.Mol Carcinog,2011,50(9):655-667.
  • [9]Kim DS,Franklyn JA,Stratford AL,et el.Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer.J Clin Endocrinol Metab,2006,91 (3):1119-1128.
  • [10]Cbalkiadaki G,Nikitovic D,Berdiaki A,et al.Fibroblast growth factor-2 modulates melanoma adhesion and migration through a syndecan-4-dependent mechanism.Int J Biochem Cell Biol,2009,41(6):1323-1331.
  • [11]Chamaon K,Kanakis D,Mawrin C,et al.Transcripts of PTTG and growth factors bFGF and IGF-1 are correlated in pituitary adenomas.Exp Clin Endocrinol Diabetes,2010,118 (2):121-126.
  • [12]Liang M,Chen X,Liu W,et al.Role of the pituitary tumor transforming gene 1 in the progression of hepatocellular carcinoma.Cancer Biol Ther,2011,11 (3):337-345.
  • [13]Fujii T,Nomoto S,Koshikawa K,et al.Overexpression of pituitary tumor transforming gene 1 in HCC is associated with angiogenesis and poor prognosis.Hepatology,2006,43 (6):1267-1275.
  • [14]Rey MC,Bonamigo RR,Cartell A,et al.MMP-2 and TIMP-2 in cutaneous melanoma:association with prognostic factors and description in cutaneous metastases.Am J Dermatopathol,2011,33(4):413-414.
  • [15]Malik MT,Kakar SS.Regulation of angiogenesis and invasion by human Pituitary tumor transforming gene (PTTG) through increased expression and secretion of matrix metalloproteinase-2 (MMP-2).Mol Cancer,2006,5:61.
  • [16]Yan S,Zhou C,Lou X,et al.PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma.Cancer Res,2009,69(8):3283-3290.
  • [17]Ito T,Shimada Y,Kan T,et al.Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma.Cancer Res,2008,68 (9):3214-3224.
  • [18]Kaur S,Martin-Manso G,Pendrak ML,et al.Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.J Biol Chem,2010,285(50):38923-38932.
  • [19]Panguluri SK,Kakar SS.Effect of PTTG on endogenous gene expression in HEK 293 cells.BMC Genomics,2009,10:577.
  • [20]Noike T,Miwa S,Soeda J,et al.Increased expression of thioredoxin-1,vascular endothelial growth factor,and rcdox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.Hum Pathol,2008,39 (2):201-208.
  • [21]Kim KB,Chesney J,Robinson D,et al.Phase Ⅰ/Ⅱ and pharmacodynamic study of dovitinib (TKI258),an inhibitor of fibroblast growth factor receptors and VEGF receptors,in patients with advanced melanoma.Clin Cancer Res,2011,17(23):7451-7461.
  • [22]Tarhini AA,Frankel P,Margolin KA,et al.Aflibercept (VEGF Trap) in inoperable stage Ⅲ or stage iv melanoma of cutaneous or uveal origin.Clin Cancer Res,2011,17(20):6574-6581.
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