Regulatory T cells and T helper 17 cells in psoriasis

( views:1255, downloads:0 )
L(U) Yun-tong(Department of Dermatology, Military General Hospital of Beijing PLA, Beijing 100125; Anhui Medical University, China)
WANG Wen-ling(Department of Dermatology, Military General Hospital of Beijing PLA, Beijing 100125)
Journal Title:
International Journal of Dermatology and Venereology
Volume 38, Issue 05, 2012
Key Word:
T-lymphocytes; Th17 cells; Psoriasis

Abstract: Psoriasis is an autoimmune disease associated with T lymphocytes.Recent research has shown that besides T helper type 1 cells,regulatory T (Treg) cells,especially the Treg and T helper 17 (Th17) cells whose generation is induced by the forkhead-box/winged-helix transcription factor Foxp3,play an essential role in the pathogenesis of psoriasis.Among them,Foxp3 + Treg cells play a key role in the exacerbation of psoriasis when the balance between immunosuppression and immune activation is shifted.The cytokines produced by Th17 cells,including interleukin (IL)-17A,IL-17F,IL-22,IL-23,IL-36,tumor necrosis factor (TNF)-α,and so on,play important roles in the initiation and progression of dermatoses.Psoriasis is a muhifactorial disease with the collaborative involvement of many immune cells including Treg and Th17 cells,as well as cytokines.

  • [1]Yan KX,Fang X,Han L,et al.Foxp3+ regulatory T cells and related cytokines differentially expressed in plaque vs.guttate psoriasis vulgaris.Br J Dermatol,2010,163(1):48-56.
  • [2]Zhang L,Yang XQ,Cheng J,et al.Increased Th17 cells are accompanied by FoxP3 (+) Treg cell accumulation and correlated with psoriasis disease severity.Clin Immunol,2010,135 (1):108-117.
  • [3]Chen L,Shen Z,Wang G,et al.Dynamic frequency of CD4+CD25 +Foxp3 + Treg cells in psoriasis vulgaris.J Dermatol Sci,2008,51 (3):200-203.
  • [4]Yun WJ,Lee DW,Chang SE,et al.Role of CD4CD25FOXP3 Regulatory T Cells in Psoriasis.Ann Dermatol,2010,22 (4):397-403.
  • [5]Miossec P,Kom T,Kuchroo VK.Interleukin-17 and type 17 helper T cells.N Engl J Med,2009,361 (9):888-898.
  • [6]Shi X,Jin L,Dang E,et al.IL-17A upregulates keratin 17 expression in keratinocytes through STAT1-and STAT3-dependent mechanisms.J Invest Dermatol,2011,131(12):2401-2408.
  • [7]Mabuchi T,Takekoshi T,Hwang ST.Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis.J Immunol,2011,187 (10):5026-5031.
  • [8]Piskin G,Sylva-Steenland RM,Bos JD,et al.In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions:enhanced expression in psoriatic skin.J Immunol,2006,176(3):1908-1915.
  • [9]Carrier Y,Ma HL,Ramon HE,et al.Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo:implications in psoriasis pathogenesis.J Invest Dermatol,2011,131 (12):2428-2437.
  • [10]Bovenschen HJ,van de Kerkhof PC,van Erp PE,et al.Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin.J Invest Dermatol,2011,131 (9):1853-1860.
  • [11]Soler DC,McCormick TS.The dark side of regulatory T cells in psoriasis.J Invest Dermatol,2011,131(9):1785-1786.
  • [12]Ziegler SF,Buckner JH.FOXP3 and the regulation of Treg/Th 17differentiation.Microbes Infect,2009,11 (5):594-598.
  • [13]Leonardi CL,Kimball AB,Papp KA,et al.Efficacy and safety of ustekinumab,a human interleukin-12/23 monoclonal antibody,in patients with psoriasis:76-week results from a randomised,double-blind,placebo-controlled trial (PHOENIX 1).Lancet,2008,371 (9625):1665-1674.
  • [14]Quaglino P,Bergallo M,Ponti R,et al.Th1,Th2,Th17 and regulatory T cell pattern in psoriatic patients:modulation of cytokines and gene targets induced by etanercept treatment and correlation with clinical response.Dermatology,2011,223 (1):57-67.
  • [15]Jetten AM.Immunology:A helping hand against autoimmunity.Nature,2011,472(7344):421-422.
  • [16]Miyoshi K,Takaishi M,Nakajima K,et al.Stat3 as a therapeutic target for the treatment of psoriasis:a clinical feasibility study with STA-21,a Stat3 inhibitor.J Invest Dermatol,2011,131 (1):108-117.
  • [17]Ghoreschi K,Brück J,Kellerer C,et al.Fumarates improve psoriasis and multiple sclerosis by inducing type Ⅱ dendritic cells.J Exp Med,2011,208(11):2291-303.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615