Aryl hydrocarbon receptor participates in the development of autoimmune dermatoses: an update on mechanisms

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WANG Xiao-wen(Department of Dermatology, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, China)
LI Chun-ying(Department of Dermatology, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, China)
GAO Tian-wen(Department of Dermatology, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, China)
Journal Title:
International Journal of Dermatology and Venereology
Volume 38, Issue 05, 2012
Key Word:
Autoimmune dermatosis; Receptors, aryl hydrocarbon; Th17 cells

Abstract´╝Ü Aryl hydrocarbon receptor,a cytosolic transcription factor,takes part in many biological processes including immune response,endocrine secretion,melanin synthesis and metabolism of low-molecular-weight molecules.Recent research has confirmed that aryl hydrocarbon receptor can interfere with immune system and result in allergic reaction and autoimmune response via interacting with low-molecular-weight chemicals.Also,aryl hydrocarbon receptor plays an important role in the development of autoimmune dermatoses.The authors review aryl hydrocarbon receptor signaling pathway,immunological functions and its association with autoimmune dermatoses,which may help to understand the pathogenesis of autoimmune dermatoses,and offer new ideas for immunotherapy of diseases.

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