Arsenic in the treatment of some kinds of dermatoses

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LUAN Li(Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China)
ZHANG Zhen-ying(Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China)
LIU Xiao-ming(Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China)
Journal Title:
International Journal of Dermatology and Venereology
Volume 38, Issue 05, 2012
Key Word:
Arsenicals; Psoriasis; Lymphoma, T cell, cutaneous; Melanoma

Abstract: Arsenic has shown some medicinal properties in psoriasis,cutaneous T cell lymphoma,melanoma,and so on.On the one hand,arsenic at certain concentrations can suppress cell growth,induce cell apoptosis and cause the regression of skin neoplasms.On the other hand,arsenic has cytotoxicity,and can be accumulated in and induce damages to yarious organs of the human body.Epidemiological studies have shown that arsenic may be carcinogenic.Therefore,more basic research and clinical trials are warranted to optimize the therapeutic dose of arsenic so as to minimize its side effects.Individualized administration of arsenic based on gene polymorphisms associated with its side effects may enable arsenic to be an effective treatment option for some kinds of skin disorders with minimal risk.

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