Abstract： Two cases of granulomatous perioral dermatitis are reported.A 6-year-old boy presented with erythema and papules on the face for 5 months,which had been exacerbated after application of topical glucocorticoids.The other patient was a 28-year-old woman,who presented with erythema and papules around the mouth and nose for more than 2 months.Small pink indurated papules measuring 1 to 3 mm in diameter were observed in the periorificial region of both patients.Histopathologic examination of the lesions showed granulomatous changes of epithelioid cells around the follicles in dermis.Both cases were diagnosed as granulomatous perioral dermatitis based on the clinical manifestation and histopathological findings.The lesions in patient 1 completely subsided after 2 months of treatment with oral erythromycin 200 mg 4 times daily as well as topical clindamycin 1％ gel and tacrolimus 0.03％ ointment,but recurred one month later.The other patient experienced a spontaneous regression of lesions,which hinted a trend to spontaneous cure of this entity.