Paper - WANFANG MED ONLINE

You Position: Home > Paper

Calcineurin inhibitors in the treatment of vitiligo

( views:453, downloads:327 )

Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-4173.2011.04.008

Key Word:: 白癜风;他克莫司;吡美莫司;治疗;Vitiligo;Tacrolimus;Pimecrolimus;Therapy

Abstract： Vitiligo is an acquired hypopigmented disease characterized by the destruction of melanocytes.Many scholars consider that the pathogenesis of vitiligo is mainly associated with immune abnormalities.Topical calcineurin inhibitors have favorable efficacy in the treatment of vitiligo,and the efficacy is associated with the treatment regimen,course,application sites,duration and stage of vitiligo,etc.The combination with narrow-band ultraviolet B,308-nm excimer laser or other therapies may have synergistic effect on the efficiency of calcineurin inhibitors.Although calcineurin inhibitors are safe and effective in the treatment of vitiligo,further studies are needed to evaluate their long-term safety and stability.

Reference

[1]吴辛刚,许爱娥.外用他克莫司软膏治疗口周白癜风后腹泻一例[J].2010,(6).
[2]Hui Lan Y,Jian Yong F,Zong Rong L,etc.Combination of 308-nm excimer laser with topical pimecrolimus for the treatment of childhood vitiligo.[J].2009,26(3).
[3]Xu AE,Zhang DM,Huang B,etc.Efficacy and safety of tarcrolimus cream 0.1% in the treatment of vitiligo.[J].2009,48(1).
[4]Daraei Z,Hosseini SH,Esfandiarpour I,etc.The efficacy of pimecrolimus 1% cream combined with microdermabrasion in the treatment of nonsegmental childhood vitiligo: a randomized placebo-controlled study.[J].2009,26(3).
[5]A R, Hossani-Madani,R M, Halder.Topical treatment and combination approaches for vitiligo: new insights, new developments.[J].2010,145(1).
[6]Breier Maly J,Radakovic S,Konschitzky R.Response of vitiligo to once- vs. twice-daily topical tacrolimus: a controlled prospective, randomized, observer-blinded trial.[J].2009,23(8).
[7]Tas T,Akkaya VB,Adiloglu AK,etc.The role of helper and regulatory T cells in the pathogenesis of vitiligo.[J].2009,60(2).
[8]Ekhlasi A,Farajzadeh S,Shamsadini S,etc.The efficacy of pimecrolimus 1% cream plus narrow-band ultraviolet B in the treatment of vitiligo: a double-blind, placebo-controlled clinical trial.[J].2009,20(1).
[9]Mun SK,Kim BJ,Kim CW,etc.Topical immunomodulators are effective for treatment of vitiligo.[J].2008,35(8).
[10]Wollenberg A,Haberstok J,Sharma S,etc.Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis.[J].2001,107(3).
[11]Keiichi, Mitsuyama,Nobuo, Tomiyasu,Kosuke, Takaki,etc.Interleukin-10 in the pathophysiology of inflammatory bowel disease: increased serum concentrations during the recovery phase.[J].2006,2006(6).
[12]J-C, Li,A-E, Xu.Facial acne during topical pimecrolimus therapy for vitiligo.[J].2009,34(7).
[13]Majid I.Does topical tacrolimus ointment enhance the efficacy of narrowband ultraviolet B therapy in vitiligo? A left-right comparison study.[J].2010,26(5).
[14]Maryann, Mikhail,Jedd, Wolchok,Stacie M, Goldberg,etc.Rapid enlargement of a malignant melanoma in a child with vitiligo vulgaris after application of topical tacrolimus.[J].2008,144(4).
[15]Kurumlu,Z.,K?se,O.,Arca,E..Mometasone cream versus pimecrolimus cream for the treatment of childhood localized vitiligo[J].2010,21(3).
[16]Griffiths CE,Marsland AM.The macrolide immunosuppressants in dermatology: mechanisms of action.[J].2002,12(6).
[17]Ghanem G,Fouty E,Picardo M,etc.Time-kinetic study of repigmentation in vitiligo patients by tacrolimus or pimecrolimus.[J].2010,302(2).
[18]Anke, Hartmann,Eva-Bettina, Br?cker,Henning, Hamm.Occlusive treatment enhances efficacy of tacrolimus 0.1% ointment in adult patients with vitiligo: results of a placebo-controlled 12-month prospective study.[J].2008,88(5).