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Allergen analysis in 816 patients with chronic allergic dermatoses

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Author:
No author available
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
5
DOI:
10.3760/cma.j.issn.1673-4173.2010.05.003
Key Word:
皮肤试验;点刺;变应原;观察;Skin tests;Pricking needling;Allergens;Observation

Abstract: Objective To assess the distribution of common allergens in atopic dermatitis, chronic urticaria and chronic eczema. Methods Skin prick tests were performed on the flexor surface of forearm of 816 patients with different chronic allergic dermatoses (including atopic dermatitis, chronic urticaria and chronic eczema) using standard allergen extracts, 0.1% histamine solution (positive control ) and physiological saline (negative control). Statistical analysis was carried out by the chi-square test. Results The sensitization rate to dust mite, which varied from 50.0% to 78.6%, was highest among the tested allergens, followed by that to animal hair (7.1%-21.4%) and mould (7.1%-14.3%). Also, statistically different sensitization rates to these three allergens were observed between patients with atopic dermatitis, chronic urticaria and chronic eczema (all P < 0.01 ), and atopic dermatitis patients showed the highest sensitization rate to all the three allergens. No significant difference was observed in the sensitization rate to shrimp among the three groups of patients (P > 0.05), although among food allergens, it was the most common sensitizing allergen with a sensitization rate of 6.6% to 14.3%. A relative increment was observed in the sensitization rate to tuna (9.5%)in patients with urticaria as well as in that to egg, milk and celery (7.1%-14.3%) in patients with atopic dermatitis; furthermore, a statistical difference was noted in the sensitization rate to the four allergens among the three groups of patients (all P < 0.05). Conclusions Inhaled allergens are common sensitizing agents in chronic allergic skin diseases; dust mite predominates in these allergens, especially in patients with atopic dermatitis who exhibit the highest sensitization rate.

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