Abstract: Treatment of SLE is versatile.B-lymphocyte-targeted therapy is a new clinical approach which has not been generally applied in China.International studies have proved it to be highly effective,safe and tolerable.So.it shows a fine application prospect and is expected to offer a new treatment approach to patients with SLE,especially to those resistant to conventional therapy and those suffering from serious adverse side effects.The true efficacy and long-term side effects of this approach remain to be further evaluated via large-scale trials and long-term follow-up.