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BAG-1 protein and cutaneous tumors

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Author:
No author available
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
1
DOI:
10.3760/cma.j.issn.1673-4173.2009.01.012
Key Word:
皮肤肿瘤;BAG-1蛋白质类;Skin neoplasms;BAG-1 proteins

Abstract: BAG-1 protein is a multi-functional protein,which can interact with a wide range of cellular targets including heat shock protein 70,anti-apoptotic BCL-2 protein,nuclear hormone receptors,growth factors,RAF and components of ubiquitylation/proteasome machinery,and subsequently inhibit cell apoptosis,cellular response to several stimuli.affect the transactivity of nuclear hormone receptor.and to regulate signal pathway and protein degradation.Clinical and laboratory studies have shown that BAG-1 protein is overexpressed in many tumors.and plays a vital role in the pathogenesis and development of tumors as well as the response of patients to chemotherapy.

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