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Peroxisome proliferator-activated receptor-gamma agonists in the treatment of dermatoses

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Author:
No author available
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
6
DOI:
10.3760/cma.j.issn.1673-4173.2008.06.004
Key Word:
过氧化物酶体增殖物激活受体;皮肤疾病;治疗;Peroxisome proliferator-activated receptors;Skin diseases;Therapy

Abstract: Recent data have shown that peroxisome proliferator-activated receptor (PPAR)-gamma regulates many biological processes in skin, including cell proliferation and differentiation, immune response and inflammatory reactions. Thus, it may serve as a novel target for the treatment of various skin disorders. Clinically, PPARgamma agonists have been used to treat psoriasis, psoriatic arthritis, atopic dermatitis, melanoma, hirsutism, vascular tumors and lipodystrophy. Investigations into PPAR agonists may develop new approaches to the treatment of skin disorders.

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