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Topical antimicrobial photodynamic therapy in dermatology
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2007.05.003
- Key Word:
- 光化学疗法;光敏感药;抗感染药,局部
Abstract： 随着新型光敏剂的开发和应用,以及治疗技术的改进,光动力疗法不仅可治疗增生性疾病,而且可治疗一些由微生物引起的局部感染性疾病.局部抗微生物光动力疗法是皮肤科近年来新兴的治疗手段,其基本原理为新型阳离子光敏剂可被细菌、真菌、病毒等病原微生物表面或其感染组织吸收、聚集,在适当波段的光照作用下产生单线态氧而杀伤病原体.对该疗法治疗作用、耐受性和遗传毒性相关的体外、动物及临床研究进行综述,并讨论光耐受性和应用中可能存在的问题.
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