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Positive Pleiotropic Effects of Statins in the Treatment of Skin Diseases

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 3

DOI:: 10.3760/cma.j.issn.1673-4173.2006.03.003

Key Word:: 他汀类药物;免疫调节;胶原;代谢

Abstract：他汀类药物是目前广泛应用于临床的降脂药物.随着在临床上的广泛应用,他汀类药物的非降脂作用渐渐被人们认识,其应用范围不断扩展,对它们的研究也逐渐深入.他汀类药物具有以下功能:①能够清除氧自由基,阻断白细胞的趋化作用、抑制抗原提呈、抑制淋巴细胞活化和相关细胞因子表达的作用,从而具有调节免疫的功能.②保护血管内皮细胞、抑制血栓形成从而能够改善血管功能.③调节成纤维细胞的胶原代谢,具有较强的抗增殖作用.他汀类药物的上述作用,使其有望成为一种能够治疗多种皮肤病的药物.

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