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Animal Models and Mycosis Research

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 2

DOI:: 10.3760/cma.j.issn.1673-4173.2006.02.005

Key Word:: 真菌病;动物替代试验

Abstract：动物疾病模型主要用于实验生理学、实验病理学和实验治疗学及新药筛选等研究,将其实验结果与人类疾病进行比较研究,有助于更方便,更有效地认识人类疾病的发生发展规律,研究防治措施.真菌病多为机会致病,但随着近年来各种诱发因素的增多,使得深部或全身播散性真菌感染日益增多.许多真菌疾病的发病机制至今还不清楚.因此,动物模型应用于真菌病研究,将为今后进一步阐明各种真菌的致病机制,为临床提供更好的治疗手段打下基础.

Reference

[1]Tatsumi Y,Yokoo M,Arika T,etc.In vivo fungicidal effect of KP-103 in a guinea pig model of interdigital tinea pedis determined by using a new method for removing the antimycotic carryover effect[J].2002,46(7).
[2]Giusiano G,Quindos G,Ezkurra PA,etc.Sertaconazole: updated review of a topical antifungal agent.[J].2005,3(3).
[3]George S, Deepe,Reta S, Gibbons.Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum.[J].2002,70.
[4]M, Feldmesser,Y, Kress,P, Novikoff,etc.Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection.[J].2000,68.
[5]Paul L, Fidel,Melissa, Barousse,Terri, Espinosa,etc.An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis.[J].2004,72.
[6]D, Svecová.[Experimental Trichophyton rubrum infection in animals].[J].2000,49.
[7]Howell KJ,Williams PL,Clemons KV,etc.Comparative efficacies of terbinafine and fluconazole in treatment of experimental coccidioidal meningitis in a rabbit model.[J].2000,44(11).
[8]Waldorf A R,Ruderman N,Diamond R D.Specific susceptibility to mucormycosis in murine diabetes and bronchoalveolar macrophage defense against Rhizopus.[J].1984.
[9]A, Treiber,W, Pittermann,H C, Schuppe.Efficacy testing of antimycotic prophylactics in an animal model.[J].2001,204(4).
[10]Cardona-Castro N.,Agudelo-FLOrez P..Development of a chronic chromoblastomycosis model in immunocompetent mice[J].1999.
[11]Fierer.Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice.[J].1999,67.
[12]Brad, Spellberg,Ashraf S, Ibrahim,John E, Edwards,etc.Mice with disseminated candidiasis die of progressive sepsis.[J].2005,192.
[13]K V,Clemons.Comparative efficacy of amphotericin B colloidal dispersion and amphotericin B deoxycholate suspension in treatment of murine coccidioidomycosis.[J].1991,35.
[14]Clayton B, Green,Xiaomin, Zhao,Lois L, Hoyer.Use of green fluorescent protein and reverse transcription-PCR to monitor Candida albicans agglutinin-like sequence gene expression in a murine model of disseminated candidiasis.[J].2005,73.
[15]Netea MG,Van der Meer JW,van Krieken JH,etc.Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells.[J].2004,172(6).
[16]Cutright JL,Tait L,Fidel PL Jr,etc.A murine model of Candida glabrata vaginitis.[J].1996,173(2).
[17]Flavia,De Bernardis.Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis.[J].2002,70.
[18]Yamaguchi H,Tanaka T,Uchida K.Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis[J].2003,47(2).
[19]Arika T,Yamaguchi H,Tatsumi Y,etc.In vitro antifungal activity of KP-103, a novel triazole derivative, and its therapeutic efficacy against experimental plantar tinea pedis and cutaneous candidiasis in guinea pigs.[J].2001,45(5).
[20]Toshiro Majima,Shigeki Masui,Katsuhisa Uchida,etc.A novel mycological analysis valuable for evaluating therapeutic efficacy of antimycotics against experimental dermatophytosis in guinea pigs[J].2005,48(2).
[21]Alexandra I,Medeiros.Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis.[J].2004,72.
[22]Clemons KV,Stevens DA.Efficacies of sordarin derivatives GM193663, GM211676, and GM237354 in a murine model of systemic coccidioidomycosis. p6[J].2000,44(7).
[23]Durkin MM,Connolly PA,Karimi K,etc.Pathogenic Differences between North American and Latin American Strains of Histoplasma capsulatum var. capsulatum in Experimentally Infected Mice.[J].2004,42(9).
[24]M, Huppert,S H, Sun,A J, Gross.Evaluation of an experimental animal model for testing antifungal substances.[J].1972,1.
[25]Sophie,Brun.Biological consequences of petite mutations in Candida glabrata.[J].2005,56.