Abstract: Plasma cell dyscrasia including multiple myeloma, monoelonal gammopathy of undetermined significance(MGUS), Waldenstrom s macroglobulinemia, amyloidosis and POEMS syndrome is a common malignant disease of hematological system and its incidence is increased by year. Deeply study the clinical process of this kind of disease and make reasonable therapies is an important approach for extending the life span and improving the prognosis of patients.