You Position: Home > Paper

Study on the mechanisms of FTI-277 inhibiting proliferation of acute myeloid leukemia cells and enhancing apoptosis induced by As2O3

( views:275, downloads:8 )
Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
1
DOI:
10.3760/cma.j.issn.1009-9921.2007.01.006
Key Word:
白血病,髓样,急性;法尼基转移酶;抑制剂;丝裂原激活蛋白激酶类;砷剂

Abstract: 目的 研究法尼基转移酶抑制剂FTI-277单独或联合三氧化二砷(As2O3)对急性髓系白血病(AML)细胞增生和凋亡的影响及其作用机制.方法 以HL-60细胞株、31例初治AML患者骨髓标本为研究对象,用四甲基偶氮唑蓝(MTT)法检测细胞增生,用流式细胞术检测细胞周期、磷酸化ERK1/2表达,用AnnexinV-FITC法、DNA琼脂糖凝胶电泳检测细胞凋亡.结果 FTI-277可明显抑制AML细胞增生,对正常细胞无明显抑制增生作用.FTI-277使AML细胞G2/M期百分数显著升高,但亚G1期细胞百分数无明显变化.FTI-277显著下调AML细胞磷酸化ERK1/2的表达,但不影响正常细胞表达.联合组与单用组相比,AML细胞凋亡率明显增高,并可检出梯状DNA条带.结论 FTI-277通过阻断AML细胞ERK/MAPK途径,使细胞发生G2/M期阻滞,抑制细胞增生.FTI-277可增强As2O3对AML细胞的凋亡诱导作用.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn