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Use of dual-color interphase FISH for the detection of inv (16) in acute myelomonocytic leukemia

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Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
1
DOI:
10.3760/cma.j.issn.1009-9921.2007.01.003
Key Word:
白血病,粒-单核细胞,急性;染色体,人,16对;倒位,染色体;原位杂交,荧光

Abstract: 目的 探讨双色荧光原位杂交(D-FISH)技术在检测急性粒-单核细胞白血病(M4)inv(16)中的价值.方法 用荧光素直接标记的双色断裂点分离的基因探针CBFβ对42例M4患者进行间期D-FISH检测,并与常规细胞遗传学进行比较分析.结果 采用R显带核型分析的42例M4患者均未发现inv(16),而D-FISH检测发现10例(23.8%)inv(16),阳性率为30.1%~98.0%,平均阳性率82.1%.5例M4Eo患者均伴有inv(16).10例阳性患者中7例核型正常,2例伴+22,1例伴+8.结论 inv(16)在M4中阳性率为23.8%,与M4Eo密切相关;用CBFβ双色探针进行D-FISH为检测inv(16)提供了有效的方法,是细胞遗传学检查的重要补充.

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