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Study on the inhibition of proliferation of human leukemia cell lines MUTZ-1 and KG1a by eight chemotherapeutic drugs
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1009-9921.2006.06.005
- Key Word:
- 骨髓增生异常综合征;急性髓系白血病变;MUTZ-1;KG1a细胞系增生
Abstract： 目的 探讨骨髓增生异常综合征急性髓系白血病变的患者对现今常用化疗药物的敏感谱.方法 应用MTT法观察Ara-C,DNR,MTZ,VP16,AMSA,HHT,IDA和TPT等8种化疗药物体外对MDS细胞系MUTZ-1及人AML细胞系KG1a的增生抑制作用.结果 两种细胞系同一种药物之间IC50值差异无统计学意义,发现HHT的两种细胞系IC50值较小,并且是8种药物中起效最快的药物,MUTZ-1和KG1a细胞24 h细胞活力分别为59.6%和81.5%.结论 HHT有可能是MDS-AML的有效治疗药物,值得进一步研究.MUTZ-1细胞系可能作为研究HHT作用机制的体外模型.
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