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Relationship between the expression of MDM2 protein, p53 protein and non-Hodgkin lymphoma in childhood
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-9921.2006.04.004
- Key Word:
- 非霍奇金淋巴瘤;癌基因MDM2;抑癌基因p53;预后
Abstract： 目的 探讨儿童非霍奇金淋巴瘤(NHL)患者癌基因MDM2和抑癌基因p53的表达与NHL的恶性程度和预后的关系.方法 46例儿童NHL患者作为病例组,12例儿童淋巴结炎患者作为对照组.用免疫组织化学超敏S-P染色法,检测病例组NHL患者、对照组淋巴结炎患者病理组织的MDM2蛋白和p53蛋白的表达情况,阳性细胞为胞核染成黄色～棕黄色,阳性细胞数≥10%为MDM2免疫组织化学阳性(MDM2蛋白过度表达);阳性细胞数＞5%为p53免疫组织化学阳性.结果 病例组MDM2蛋白过度表达率为65.2%,与对照组比较差异有统计学意义(P＜0.01).p53蛋白阳性率为19.6%,与对照组比较差异无统计学意义(P＞0.05).MDM2蛋白过度表达率在病理分类高度恶性、患者血清LDH增高之间差异均有统计学意义(P＜0.05),与患者的B状态间差异有统计学意义(P＜0.01).p53蛋白阳性率在病理工作分类、临床分期、B状态、血清LDH之间差异均无统计学意义(P＞0.05).MDM2蛋白过度表达与p53蛋白阳性之间没有关联性.结论 儿童NHL患者MDM2基因的过度表达率较高;MDM2过度表达与儿童NHL患者的不良状况、不良预后有关;儿童NHL患者p53阳性率较低.
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