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Clinical and laboratory research of two acute promyelocytic leukemia patients with isochromosome17q- anomaly
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2006.03.002
- Key Word:
- 急性早幼粒细胞白血病;染色体易位i(17q-);临床特征;实验室特征
Abstract： 目的探讨伴有i(17q-)的急性早幼粒细胞白血病(APL)的临床和实验室特征.方法骨髓细胞经24 h培养后按常规方法制备染色体,用R显带技术进行核型分析,并用PML/RARα和HER-2探针进行荧光原位杂交(FISH)检测.用反转录-聚合酶链反应(RT-PCR)检测PML/RARα融合基因.结果2例的临床和血液学改变符合AML-M3诊断.染色体核型分析揭示2例患者染色体均存在t(15;17)易位及i(17q-),并通过FISH检测加以证实.2例RT-PCR均检测到了PML/RARα融合基因.结论i(17q-)是APL中一种少见的染色体附加异常,其预后意义有待进一步讨论.
- [1]Zhijian, Xiao,Shihe, Liu,Minghua, Yu,etc.Isochromosome 17q in patients with myelodysplastic syndromes: six new cases.[J].2003,88(6).
- [2]J P, Park,R B, Fairweather,T K, Mohandas.Isochromosome for derivative 17q in acute promyelocytic leukemia: evidence for two copies of PML-RARA and favorable response to all-trans-retinoic acid therapy.[J].1997,18(2).
- [3]Kazuma Ohyashiki,Mitsuo Oshimura,Hiroyuki Uchida,etc.Cytogenetic and ultrastructural studies on ten patients with acute promyelocytic leukemia, including one case with a complex translocation[J].1985,14(3-4).
- [4]Biondi A,Gameiro P,Saglio G,etc.Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.[J].1999,13(12).
- [5]LYNNE R. HIORNS,G. JOHN SWANSBURY,JAYESH MEHTA,etc.Additional chromosome abnormalities confer worse prognosis in acute promyelocytic leukaemia[J].1997,96(2).
- [6]W C, Chou,J L, Tang,M, Yao,etc.Clinical and biological characteristics of acute promyelocytic leukemia in Taiwan: a high relapse rate in patients with high initial and peak white blood cell counts during all-trans retinoic acid treatment.[J].1997,11(7).