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The study of the morphologic features and the relationships with the Ki-67 expression and HP in gastrointestinal mucosa-associated lymphoid tissue lymphoma
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2006.02.004
- Key Word:
- 胃肠道黏膜相关淋巴组织淋巴瘤;Ki-67表达;幽门螺杆菌感染
Abstract： 目的探讨胃肠道黏膜相关淋巴组织(MALT)淋巴瘤形态特点及其与Ki-67表达、幽门螺杆菌(HP)感染的关系.方法观察22例MALT淋巴瘤的组织形态,并用免疫组织化学链菌素-卵白素生物素(SABC法)对其进行CD20,CD79a,CD3,CD45RO,CD23,CD5,CD10及Ki-67标记.采用Warthin-Starry胃幽门螺杆菌染色法对胃MALT淋巴瘤进行HP染色.结果22例MALT淋巴瘤依据组织形态分为低度恶性16例,伴高度转化6例.在低度恶性MALT淋巴瘤和伴高度恶性转化的MALT淋巴瘤两组病例中,Ki-67的阳性表达率分别为43.8%(7/16),83.3%(5/6),其阳性表达率及表达强度差异有统计学意义(P＜0.05).11例胃MALT淋巴瘤HP阳性率81.6%.结论胃肠道黏膜相关淋巴瘤有其独特的病理形态学特点及临床表现,Ki-67在胃肠道MALT淋巴瘤的诊断、组织学分级中具有重要价值;HP的感染与胃MALT淋巴瘤的关系密切.
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