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Study on hemorrhagic cystistis in allogeneic hematopoietic stem cell transplantation recipients
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-9921.2005.01.006
- Key Word:
- allo-HSCT;出血性,膀胱炎;GVHD
Abstract： 目的观察异基因造血干细胞移植(allo-HSCT)中出血性膀胱炎(HC)的发病情况,探讨其发病原因及防治效果.方法对allo-HSCT中12例次HC的危险因素和临床疗效进行分析.结果12例次HC患者中,早期HC 2例次,迟发性HC 10例次.8例出现病毒感染;10例出现急性移植物抗宿主病(GVHD),1例出现慢性GVHD.3例患者死亡,8例治愈.结论HC的发生除受环磷酰胺、白消安、TBI等的损害外,还与GVHD及病毒感染有关.在常规水化、碱化的基础之上加用美司那可降低早期HC的发生.HC的治疗除水化、碱化及利尿外,加用前列腺素E1和抗病毒治疗有效.
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