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EXPRESSION OF nm23-H1 MRNA IN CHRONIC MYELOGENOUS LEUKEMIA (CML)
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.03.005
- Key Word:
- 白血病;粒细胞;慢性;基因;nm23-H1;聚合酶链反应
Abstract： 目的:检测慢性粒细胞白血病(CML)患者nm23-H1基因表达,探讨其与临床的关系.方法:采用半定量反转录-聚合酶链反应(RT-PCR)技术检测33例慢性粒细胞白血病及10例对照nm23-H1表达.结果:慢性粒细胞白血病慢性期nm23-H1水平与正常差异无显著性(P＞0.05),慢性粒细胞白血病加速期及急变期nm23-H1表达明显增高(P＜0.01).结论:nm23-H1在慢性粒细胞白血病加速期及急变期中表达显著增高,与疾病进展相关,是预后的重要因素.
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