You Position: Home > Paper
SPLENIC MARGINAL ZONE LYMPHOMA WITH AUTOIMMUNE HEMOLYTIC ANEMIA
( views:457, downloads:97 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.02.003
- Key Word:
- 脾边缘区;淋巴瘤;B淋巴细胞
Abstract： 目的:提高对脾边缘区淋巴瘤(splenicmarginal zonelymphoma,SMZL)的认识.方法:详细报告1例典型患者临床及实验室特征,并复习相关文献.结果:SMZL是一少见的原发于脾脏的低度恶性B细胞淋巴瘤.临床以脾脏明显肿大、淋巴细胞增多为特征,易浸润骨髓,可合并自身免疫疾患.肿瘤细胞表达成熟B细胞免疫表型,CD-5、CD-10、CD-23、CD-103,不表达T细胞相关分化抗原.结论:SMZL起病潜隐,进展缓慢,生存期长,容易漏诊.糖皮质激素和环孢茵素A治疗SMZL合并自身免疫性溶血性贫血(AIHA)近期疗效好,对SMZL本身也有一定治疗作用.
- [1]J E, Coad,E, Matutes,D, Catovsky.Splenectomy in lymphoproliferative disorders: a report on 70 cases and review of the literature.[J].1993,10.
- [2]D A, Arber,H, Rappaport,L M, Weiss.Non-Hodgkin's lymphoproliferative disorders involving the spleen.[J].1997,10.
- [3]Mollejo M,Martinez P,Piris MA,etc.Molecular heterogeneity of splenic marginal zone lymphomas: analysis of mutations in the 5' non-coding region of the bcl-6 gene.[J].2001,15(4).
- [4]E, Labouyrie,G, Marit,J P, Vial,etc.Intrasinusoidal bone marrow involvement by splenic lymphoma with villous lymphocytes: a helpful immunohistologic feature.[J].1997,10(10).
- [5]Simon Bolam,Jenny Orchard,David Oscier.Fludarabine is effective in the treatment of splenic lymphoma with villous lymphocytes[J].1997,99(1).
- [6]Emanuele Zucca,Francesco Bertoni,Enrico Roggero,etc.Management of rare forms of lymphoma[J].1998,10(5).
- [7]R D, Hammer,A D, Glick,J P, Greer,etc.Splenic marginal zone lymphoma. A distinct B-cell neoplasm.[J].1996,20.
- [8]Weisenburger DD,Armitage JO.New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project.[J].1998,16(8).
- [9]Richard Gale,OwenP. Smith,Marion Wood,etc.Splenic lymphoma with villous lymphocytes complicated by autoimmune haemolytic anaemia[J].1992,340(8827).
- [10]Francois S,Varet B,Lefrere F,etc.Fludarabine: an effective treatment in patients with splenic lymphoma with villous lymphocytes.[J].2000,14(4).
- [11]Catherine, Thieblemont,Pascale, Felman,Francoise, Berger,etc.Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients.[J].2002,3(1).
- [12]V. FRANCO,A.M. FLORENA,G. CAMPESI.Intrasinusoidal bone marrow infiltration: a possible hallmark of splenic lymphoma[J].1996,29(6).
- [13]N L, Harris,E S, Jaffe,H, Stein,etc.A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.[J].1994,84.
- [14]C. Schmid,N. Kirkham,T. Diss,etc.Splenic Marginal Zone Cell Lymphoma[J].1992,16(5).
- [15]X. TROUSSARD,F. VALENSI,E. DUCHAYNE,etc.Splenic lymphoma with villous lymphocytes: clinical presentation, biology and prognostic factors in a series of 100 patients[J].1996,93(3).
- [16]Orlin J,Bendayan D,Barac Y,etc.Splenic lymphoma presenting as warm autoimmune hemolytic anemia associated with pure red cell aplasia.[J].2000,78(2).
- [17]Catovsky D,Matutes E.Splenic lymphoma with circulating villous lymphocytes/splenic marginal-zone lymphoma.[J].1999,36(2).